Is this possible?
No. This setting is applied before running Application.cfc so it is too late at that point.
You can, however, set it via an Environment variable:
SET LUCEE_FULL_NULL_SUPPORT=true # windows
EXPORT LUCEE_FULL_NULL_SUPPORT=true # *nix
or a System property (in the Java arguments):
-Dlucee.full.null.support=true
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