Basically no. If you edit server.xml you MUST restart Tomcat.
What you want to do is what @Jordan_Michaels wanted to achieve and he came uo with the idea to create mod_cfml.
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Thanks Andreas, for this information.
I have just checked my server.xml and I see that my mod_cfml valve has been commented out.
If I uncomment this, do you think, it would have any adverse effects, after I restart Tomcat?
I figure one more restart is worth it, if it means no more subsequent restarts.
I presume after this, I just need to update/add bindings in IIS, and these changes will be passed to Tomcat, via the mod_cfml valve? Oh what joy! 
To install mod_cfml you need to do various things. If you install Lucee with the installer, you’ll be asked for having it installed. Because you have the mod_,cfml commened out, I suppose it’s not fully installed. You may need to check/adapt the boncode settings and some more. Please check the mod_,cfml documentation for that
Please consider that mod_cfml is still shipped with Lucee installers, but there have been some issues that started with some patches that have been applied to Tomcarmay appear in your environement. Because @Jordan_Michaels stopped developing mod_cfml I’m not sure you’ll have some of the unresolved issues. But… if you have it installed and it works, then ot works.
Hi Andreas
I decided not to use mod_cfml, as it has always caused issues for me, in the past.
Instead I found another way of achieving my objective.
I have written about it, here: