@Schumatech , does the following test work?
<cfset wsObject=createobject("webservice","http://dev.moby.ch/webservices/mailenable/v1-4-1/mailenable.cfc?wsdl")>
<cfdump var="#wsObject#" >
If it does, then cfinvoke might be broken in Lucee 5.4.2.17. Someone reported a similar cfinvoke issue on Lucee 5.3.7.47.