I had several problems today to get Lucee 5 express running with multiple hosts.
This issue is still open:
The solution was to update the bundled Tomcat version (which is very old 8.0.14 from 2014-09-29).
There was a Tomcat bug for applications with Tomcat 8 and Apache Felix both embedded on the same JVM, which was fixed in December 2015 - https://bz.apache.org/bugzilla/show_bug.cgi?id=58692
So I would suggest to update the bundled Tomcat version in Lucee 5 Express!