We’ve experienced memory leakage issues with both 4.5 and 5.2.3.35. Upgrading to the latest 5.2.5 snapshot build seems to have solved the problems in both cases. See these two discussions for more detail:
https://lucee.daemonite.io/t/upgrade-to-lucee-5-2-3-35-results-in-gc-overhead-limit-crashes/2766